C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/290.1, 260/2
C07D 213/53 (2006.01) C07D 401/06 (2006.01)
Patent
CA 1154771
ABSTRACT 1-substituted hydroxyiminomethyl-pyridinium salts, a process for the production of said compounds, compositions with an activity against organophosphate poisonings, and a process for the preparation of such compositions. The invention provides 1-substituted hydroxyiminomethyl-pyridi- nium salts of the formula 4, wherein R1 is a substituted or unsubstituted (hetero) aryl group or a corres- ponding dihydro group, R2 is a hydrogen, an alkyl or aryl group, R3 is a hydrogen or an alkyl group and Z-is an anion suited for pharmacological purposes, pharmacological composition containing said compounds and a process for the preparation of said compounds by reacting a pyridine carboxaldoxime with a (hetero) arylhalide. The compounds in question show a good activity against nerve gases and are suited for prophylaxis too.
357153
Benschop Hendrik P.
de Jong Leonardus P.a.
Kepner Larry A.
Fetherstonhaugh & Co.
Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschap
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