1-substituted n-(8 alfa-ergolinyl)-n',n' diethyl- ureas and...

Details 1-substituted n-(8 alfa-ergolinyl)-n',n' diethyl- ureas and... 1-substituted n-(8 alfa-ergolinyl)-n',n' diethyl- ureas and...

C - Chemistry, Metallurgy

07

D

260/206

C07D 457/12 (2006.01)

Patent

CA 1203531

ABSTRACT OF THE DISCLOSURE The present invention relates to 1-substituted N-[8.alpha.-ergolinyl]-N',N'-diethylureas of the general formula (I): Image (I) wherein R1 represents alkyl group having 1 to 4 carbon atoms and R2 represents lower alkyl group having 1 to 4 carbon atoms, benzyl group, allyl group or a group of general formula -[CH2]nCOOR3, where R3 stands for hydrogen atom or alkyl group having 1 to 2 carbon atoms and n is integer 1 to 4, and to a process for their preparation. Compounds of the above general formula I exhibit dopamin- ergic action on the respective receptors, significant inhibiting effect to prolactine and growth hormone secre- tion and stimulative effect to secretion of gonadotropine.

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