1-substituted pyrazolo (3,4-c) ring compounds as modulators...

Details 1-substituted pyrazolo (3,4-c) ring compounds as modulators... 1-substituted pyrazolo (3,4-c) ring compounds as modulators...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2602590

Pyrazolo[3,4-c] ring compounds of Formula (I), e.g., pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinolines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and pyrazolo[3,4-c]naphthyridines, substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

L'invention concerne des composés cycliques pyrazolo[3,4-c] de la formule I, par exemple pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinoléines, 6,7,8,9-tétrahydro pyrazolo[3,4-c]quinoléines, et pyrazolo[3,4-c]naphtyridines, substituées en position 1, des compositions pharmaceutiques contenant ces composés, des intermédiaires, ainsi que des procédés de fabrication et d'utilisation des ces composés comme immunomodulateurs, pour induire la biosynthèse de cytokine chez les animaux et dans le traitement de maladies, notamment des maladies virales et néoplastiques.

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