1'-substituted-spiro ¬pyrrolidine-3,3'-indoline|...

Details 1'-substituted-spiro ¬pyrrolidine-3,3'-indoline|... 1'-substituted-spiro ¬pyrrolidine-3,3'-indoline|...

C - Chemistry, Metallurgy

07

D

260/306.1

C07D 487/10 (2006.01) C07D 209/34 (2006.01) C07D 209/38 (2006.01) C07D 209/42 (2006.01)

Patent

CA 1182823

ABSTRACT The invention there provides a pharmaceutical composition comprising an aldose reductase inhibitory 1'-substituted-spiro[pyrrolidine-3,3'-indoline]-2,2', 5-trione of the formula:- Image I wherein Ra is (2-7C)alkyl or (3-7C)alkenyl, naphthyl- methyl or cinnamyl optionally bearing one or two halogeno nuclear substituents, or Ra is benzyl optionally bearing one or two substituents and benzene ring A optionally bears one or two substituents, trifluoro- methyl and nitro; or a salt thereof with a base affording ? pharmaceutically acceptable cation; or a non-toxic, biodegradable precursor thereof; together with a pharmaceutically a-ceptable diluent or carrier. The invention also provides novel compounds of formula I and processes for their manufacture. The compositions are of application in the treatment or prophylaxis of the side effects of diabetes or galactosemia.

402665

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