1-sulfonyl-5(6)-substituted-benzimidazoles

Details 1-sulfonyl-5(6)-substituted-benzimidazoles 1-sulfonyl-5(6)-substituted-benzimidazoles

C - Chemistry, Metallurgy

07

D

260/305.05, 260/

C07D 235/30 (2006.01)

Patent

CA 1079737

Abstract of the Disclosure Novel 1-sulfonyl-5(6)-substituted-benzimidazoles are described herein which are useful as antiviral agents. The novel compounds are prepared by reacting the cor- responding 1-sulfonyl-5(6)-substituted-benzimidazole with a Gri?nard reagent or alkyl lithium, followed by hydrolysis, optionally followed by dehydration, and/or followed by acylation. The novel sulfonyl benzimidazole compounds have the general formula Image (I) , wherein R is C1-C4 alkyl, C5-C7 cycloalkyl, thienyl, phenyl, or -NR3R4 wherein R3 and R4 are independently C1-C3 alkyl; R1 is hydrogen, or C1-C4 acyl; R2 is Image or Image ; wherein R5 is C1-C4 alkyl, phenyl, halophenyl, or C3-C6 cycloalkyl; R6 is C1-C7 alkyl; R7 is C1-C7 alkylidene; and R2 is at the 5 or 6 position.

271307

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