1-thia-3-aza-dibenzoazulenes as inhibitors of tumour...

Details 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour... 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2486821

The present invention relates to derivatives of 1-thia-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-a (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

L'invention se rapporte à des dérivés de la classe des 1-thia-3-aza-dibenzoazulènes, à leurs sels et à leurs solvates pharmacologiquement acceptables, à des procédés et à des produits intermédiaires pour la préparation de ces composés, ainsi qu'à leurs effets anti-inflammatoires, notamment à l'inhibition de la production du facteur .alpha. de nécrose tumorale (TNF-.alpha.) et à l'inhibition de la production d'interleukine-1 (IL-1), ainsi qu'à leur action analgésique.

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