1-thio-d-glucitol derivatives

Details 1-thio-d-glucitol derivatives 1-thio-d-glucitol derivatives

C - Chemistry, Metallurgy

07

D

C07D 335/02 (2006.01) A61K 31/382 (2006.01) A61K 45/00 (2006.01) A61P 1/16 (2006.01) A61P 3/02 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 3/12 (2006.01) A61P 7/02 (2006.01) A61P 7/10 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/04 (2006.01) A61P 19/06 (2006.01) A61P 25/02 (2006.01) A61P 27/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2592995

It is intended to provide a 1-thio-D-glucitol compound represented by the following formula which shows an effect of inhibiting the activity of SGLT2, a pharmaceutically acceptable salt thereof or a hydrate thereof; and a drug containing such a compound as the active ingredient, in particular, a preventive or a remedy for diabetes, diabetes-associated diseases or diabetic complications. It is also intended to provide a method of producing the 1-thio- D-glucitol compound and an intermediate thereof.

La présente invention a pour objet un dérivé de 1-thio-D-glucitol de formule (I) qui présente un effet inhibiteur de l'activité de SGLT2. La présente invention a également pour objet un sel pharmaceutiquement acceptable dudit dérivé ou un hydrate dudit dérivé, ainsi qu'un médicament contenant un tel dérivé comme principe actif, en particulier un médicament prophylactique ou thérapeutique pour le traitement du diabète, de maladies associées au diabète ou de complications diabétiques. La présente invention a en outre pour objet une méthode de synthèse dudit dérivé de 1-thio-D-glucitol ainsi qu'un intermédiaire de ce dernier.

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