C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/453 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2374643
This invention relates to novel 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives of formula (I) wherein R1 is C1-C6 alkyl; R2 is hydrogen, C1-C6 alkyl, halo C1-C6 alkyl or phenyl; R3 is hydrogen or halo; and R4 and R5 are independently hydrogen, C1-C6 alkyl or halo C1-C6 alkyl, their pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and the use of such compounds to treat CNS, gastrointestinal and other disorders.
L'invention se rapporte à de nouveaux dérivés 1-trifluorométhyl-4-hydroxy-7-pipéridinyl-aminométhylchromane représentés par la formule (I) dans laquelle R<1> est alkyle C1-C6, R<2> est hydrogène, alkyle C1-C6, halo alkyle C1-C6 ou phényle; R<3> est hydrogène ou halo; et R<4> et R<5> sont indépendamment hydrogène, alkyle C1-C6 ou halo alkyle C1-C6. L'invention se rapporte également à des sels pharmaceutiquement acceptables de ces dérivés, à des compositions pharmaceutiques contenant de tels composés ainsi qu'à l'utilisation de ces composés pour traiter, entre autres, les troubles du système nerveux central et les troubles gastro-intestinaux.
Obach Ronald Scott
Scully Douglas Alan
Pfizer Products Inc.
Smart & Biggar
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