10-(1,2-propadienyl) steroids as irreversible aromatase...

Details 10-(1,2-propadienyl) steroids as irreversible aromatase... 10-(1,2-propadienyl) steroids as irreversible aromatase...

C - Chemistry, Metallurgy

07

J

260/36

C07J 1/00 (2006.01) C07J 21/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1173432

M-1123 ABSTRACT OF THE DISCLOSURE Irreversible aromatase inhibitors are provided having the formulae Image I II wherein Image represents a single or a double bond; R1 is CH3 or C2H5; R2 is (H)(OR8) or O; R3 is H or C1-3 alkyl; R4 is H or OR8; R5 is H2, O or (H)(C1-3 alkyl); R6 and R7 are each independently H or C1-3 alkyl; and R8 is H or C1-4 alkanoyl. Intermediates useful in preparing the foregoing aromatase inhibitors, methods of using them and a pharmaceutical composition containing them are also provided.

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