C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/125, 167/180
C07D 487/04 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07C 45/71 (2006.01) C07C 49/753 (2006.01) C07D 205/08 (2006.01) C07D 477/00 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2024880
The invention concerns compounds of general formula (I) (see formula 1) in which:- R1 represents a hydrogen atom or a hydroxyl protecting group; R2 represents a hydrogen atom or a carboxyl protecting group; and R3 represents a hydrogen atom, a hydroxyl group, a hydroxymethyl group, a C1-3alkyl group or a group XR4 in which X represents an oxygen atom or the group S(O)n in which n is zero or the integer 1 or 2 and R4 represents a C1-5alkyl, C3-7cycloalkyl or phenyl group, or when X is an oxygen or sulphur atom then R4 may also represent the group AlkNR5R6 in which Alk represents a C2-6 straight or branched alkylene chain, and R5 and R6 each independently represent a hydrogen atom or a C1-4 alkyl group or R5 represents a formyl, acetyl or iminomethyl group and R6 represents a hydrogen atom or R5 and R6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring, or R3 represents a group (CH2)mNR7R8 in which m is zero or one and R7 and R8 independently each represent a hydrogen atom or a C1-4 alkyl group or R7 represents a formyl, acetyl or iminomethyl group and R8 represents a hydrogen atom, or R3 and the carbon atom to which it is attached represent a keto group or a ketal derivative thereof; and salts (including internal salts where appropriate), metabolically labile esters and solvates thereof and a process for their production.
Andreotti Daniele
Bismara Claudio
Carlesso Roberto
Donati Daniele
Gaviraghi Giovanni
Fetherstonhaugh & Co.
Glaxo S.p.a.
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