C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/4741 (2006.01) A61K 31/4745 (2006.01)
Patent
CA 2395980
Camptothecin compounds having a C10 11 O-(CF2)nO group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
La présente invention concerne des composés de camptothécine qui possèdent un groupe C¿10? ¿11? O-(CF¿2?)¿n?O dans lequel n est 1 ou 2, et qui sont des composés anti-tumoraux efficaces. Ces composés inhibent l'enzyme topoisomérase I et peuvent être un ADN d'alcoylat du complexe clivable associé topoisomérase I-ADN.
Balasubramanian Neelakantan
Manikumar Govindarajan
Vyas Dolatrai
Wall Monroe E.
Wani Mansukh C.
Bristol-Myers Squibb Company
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Research Triangle Institute
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