10,11-dihydro-5h-dibenzo(a,d) cyclohepten-5,10-imines

Details 10,11-dihydro-5h-dibenzo(a,d) cyclohepten-5,10-imines 10,11-dihydro-5h-dibenzo(a,d) cyclohepten-5,10-imines

C - Chemistry, Metallurgy

07

C

260/200.1

C07C 211/32 (2006.01) C07D 451/02 (2006.01)

Patent

CA 1142516

10,11-DIHYDRO-5H-DIBENZO[a,d]- CYCLOHEPTEN-5,10-IMINES CASE NO. 16344 ABSTRACT OF THE DISCLOSURE: 10,11-Dihydro-5H-dibenzo[a,d]cyclo- hepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease. They are prepared by treatment of a 5H-dibenzo[a,d]cyclohepten-5-one with ammonia to give the 5-imine, acylation of the imine, treatment of the protected imine with an organolithium to provide the 5-substituted-5-acylamino compound, treatment with acid or base to cause ring closure to a 5-substituted-5,10-acylimino compound followed by removal of the protecting group, either hydrolyti- cally or hydrogenolytically.

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