10-alkynyl steroids

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C - Chemistry, Metallurgy

07

J

260/36

C07J 1/00 (2006.01) C07J 21/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1173431

M-1122 -Cl ABSTRACT OF THE DISCLOSURE Aromatase inhibitors are provided having the formula Image wherein Image represents a single or double bond; R is hy- drogen or C1-4 alkyl; R1 is methyl or ethyl; R2 is (H)(OR8) or =O; R3 is H or C1-3 alkyl; R4 is H or OR8; R5 is H, C1-3 alkyl or, when the 5,6-bond is saturated, R5 is divalent =O; R6 and R7 are each H or C1-3 alkyl; and R8 is H or C2-4 alkanoyl. Intermediates useful in preparing the foregoing aromatase inhibitors, and methods of using the aromatase inhibitors of the invention are also provided.

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