10.beta.-alkynylestrene derivatives and process for their...

C - Chemistry – Metallurgy – 07 – J

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167/198, 260/31

C07J 1/00 (2006.01) A61K 31/565 (2006.01) C07J 21/00 (2006.01) C07J 41/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1310957

ABSTRACT The invention relates to 6-substituted 10.beta.- alkynylestrene derivatives wherein the 6 substituent is amino, azido, halogen or an alkylidene group and to corresponding 6,7- dihalo analogs. The invention provides also a process for the preparation of the above compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.

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