10-bromosandwicine, 10-bromoisosandwicine, methods for...

Details 10-bromosandwicine, 10-bromoisosandwicine, methods for... 10-bromosandwicine, 10-bromoisosandwicine, methods for...

C - Chemistry, Metallurgy

07

D

260/241.1

C07D 459/00 (2006.01) C07D 471/22 (2006.01)

Patent

CA 1147331

Abstract of the Disclosure 10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. These novel compounds are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. The novel compounds themselves also possess similar pharmacological properties. 10-bromosandwicine is prepared by brominating sandwi- cine and can subsequently be isomerized into 10-bromoiso- sandwicine.

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