10-desacetoxytaxol derivatives

Details 10-desacetoxytaxol derivatives 10-desacetoxytaxol derivatives

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07F 7/00 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2119363

The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have formula (1) wherein R2 is hydrogen, hydroxy or a protected hydroxy group; R3 and R4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, -SH, -NH2, or -NR8R9; R5 is R10, or -OR10; R6 and R7 are inde- pendently hydrogen, alkyl, or aryl; R8 and R9 ace independently hydrogen, alkyl, alkenyl, alkynyl, or aryl; and R10 is al- koxy, alkyl, alkenyl, alkynyl, or aryl.

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