103p2d6: tissue specific protein highly expressed in various...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2400443

A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2SD6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.

L'invention se rapporte à un nouveau gène (dénommé 103P2D6) et à la protéine codée par ledit gène. La protéine 103P2D6 n'est pas exprimée dans un tissu adulte normal, mais elle est fortement exprimée dans des hétérogreffes de tissus prostatiques, ce qui est une preuve qu'elle est transformée en cancer prostatique. Cette protéine 103P2D6 est également exprimée dans certains tissus foetaux, et dans les cancers du sein, de la vessie, du poumon, des os, du colon, du pancréas, des testicules, du col de l'utérus et des ovaires. Cette protéine 103P2D6 constitue par conséquent une cible aux fins de diagnostic et/ou de traitement de cancers, et le gène 103P2D6 ou un fragment de ce gène, ou la protéine qu'il code ou un fragment de cette protéine peuvent être utilisés pour provoquer une réaction immunitaire.

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