11-12 bicyclic erythromycin derivatives

C - Chemistry – Metallurgy – 07 – H

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C07H 17/08 (2006.01) A61K 31/70 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2531561

The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

La présente invention concerne des composés représentés par la formule (I) ou les sels, les esters ou les promédicaments pharmaceutiquement acceptables de ces derniers qui présentent des propriétés antibactériennes; les compositions pharmaceutiques comprenant lesdits composés destinées à être administrées à un sujet nécessitant un tel traitement. Cette invention se rapporte également à des méthodes de traitement d'une infection bactérienne chez un sujet qui consiste à administrer une composition pharmaceutique comprenant les composés selon l'invention. Ladite invention concerne également un procédé de production des composés selon l'invention. Formule (I)

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