11,12-difluoromethylene substituted prostanoic and...

Details 11,12-difluoromethylene substituted prostanoic and... 11,12-difluoromethylene substituted prostanoic and...

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 317/30 (2006.01) C07C 405/00 (2006.01) C07D 307/935 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1077035

11,12-DIFLUOROMETHYLENE SUBSTITUTED PROSTANOIC AND PROST-5-CIS-ENOIC ACID DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF Abstract of the Disclosure Novel racemic and antimeric prostaglandin analogs having a difluoromethylene group attached to the C-11,12 positions of the molecule, and oxygenated functions at C-9 and C-15, which may be further substituted at C-15 by a methyl group and process for the production of such compounds. Also included are the lower alkyl esters of the carboxylic acid function and pharmaceutically acceptable salts thereof. These compounds posses prostaglandin-like activities and thus are useful in the treatment of mammals, where prostaglandins are indicated.

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