11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetr...

Details 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetr... 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetr...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2746058

The present invention relates to certain salts of a 11-(2-pyrrolidin-1-yl- ethoxy)-14,19- dioxa-5,7,26-triaza-tetracy-clo[19.3.1.1 (2,6).1 (8, 12)]heptacosa- 1 (25),2(26),3,5,8,10,12(27),16,21,23-decaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

L'invention concerne certains sels d'un 11-(2-pyrrolidin-1-yl-éthoxy)-14,19- dioxa-5,7,26-triaza-tétracyclo[19.3.1.1 (2,6).1 (8, 12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaène (composé I) qui s'avèrent présenter des propriétés améliorées. En particulier, l'invention concerne le sel de citrate de ce composé. L'invention concerne également des compositions pharmaceutiques contenant ledit sel de citrate et des procédés d'utilisation de ce sel pour le traitement de certains troubles médicaux.

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