11,21-bisphenyl-19-norpregnane derivatives

Details 11,21-bisphenyl-19-norpregnane derivatives 11,21-bisphenyl-19-norpregnane derivatives

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 31/00 (2006.01) C07J 43/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2149496

The invention relates to a 11,21-bisphenyl-19-nor- pregnane derivative of formula I (See formula I) wherein R1 is selected from H, halogen, (1-6C)alkoxy, and NR5R6, R5 and R6 being independently hydrogen or (1-6C)alkyl or R5 and R6 together are (3-6C)alkylene; R2 is hydrogen; or R1 and R2 together are a (1- 3C)alkylenedioxy group, optionally substituted by one or more halogen atoms; R3 is methyl or ethyl; R4 is selected from C(O)-NR5R6, SO n-(1-6C)alkyl optionally substituted by one or more. halogen atoms, SO n-(3-6C)cycloalkyl, n being 1 or 2, SO2-NR5R6, 2-oxypyrrolidinyl, and NR5R6; R7 is H or (1-6C)alkyl; R8 is H or carboxy-1-oxo(1-6C)alkyl; and X is selected from (H,OH), O, and NOH; 11 or a pharmaceutically acceptable salt thereof. The compounds of the invention have anti-glucocorticoid activity and can be used in treating or preventing glucocorticoid-dependent diseases.

Affiliated with

Also associated with

Rating

11,21-bisphenyl-19-norpregnane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 11,21-bisphenyl-19-norpregnane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 11,21-bisphenyl-19-norpregnane derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1821780