11.alpha.-amino-androstanes

Details 11.alpha.-amino-androstanes 11.alpha.-amino-androstanes

C - Chemistry, Metallurgy

07

J

260/4, 260/59

C07J 41/00 (2006.01) C07J 63/00 (2006.01)

Patent

CA 1173433

ABSTRACT "11.alpha.-amino-androstanes" Compounds of formula Image (I) (wherein: R1 is a C1-8 alkyl group or a C3-7 cycloalkyl group; R2 is a hydrogen atom, a C1-6 alkoxy group or a C2-5 alkanoyloxy group, and R3 is a C1-8 alkyl group or a C3-7 cycloalkyl group; provided that when the compounds contain a 5.beta.-hydrogen atom, R2 is a hydrogen atom, and.the D-homo analogues thereof having the group -CO2R3 (wherein R3 is as defined above) at the 17a.beta.- position, and salts thereof have activity as antidysrhythmic agents and may be applicable for treatment of ventricular dysrhythmias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers and exoipients and may be prepared by a variety of processes known for producing steroids of this type. The invention also provides intermediates for the preparation of the compounds of formula (I), wherein R3 and/or R1 are replaced with hydrogen atoms, and processes for the preparation of such intermediates.

381747

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