11.beta.-alkynl-estrenes and -estradienes, their production,...

Details 11.beta.-alkynl-estrenes and -estradienes, their production,... 11.beta.-alkynl-estrenes and -estradienes, their production,...

C - Chemistry, Metallurgy

07

J

167/191, 260/31,

C07J 1/00 (2006.01) A61K 31/56 (2006.01) C07J 17/00 (2006.01) C07J 21/00 (2006.01) C07J 31/00 (2006.01) C07J 33/00 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1326014

(1) Abstract of the Disclosure 11.beta.-substituted steroids of the formula Image wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is 0, two H atoms or hydroximino; Z is the residue of a pentagonal or hexagonal ring which is optionally substituted and optionally saturated; R1 is vinyl, C3-7-cyclo-1-alkenyl, phenyl, naphthyl or 5- or 6-membered heterocyclic aromatic having at least one N, O or S atom, each being unsubstituted or substituted by 1-3 halogen atoms, 1-3 C1-4-alkyl, C1-4-alkoxy, C1-4-acyl, C2-10-alkenyl, C1-4-acyloxy, phenyl, nitro, hydroxy, carboxy, cyanide, COOR4 or amino optionally substituted by 1-2 C1-4-alkyl; R2 is methyl or ethyl, R3 is H, Cl or methyl; and (2) R4 is C1-4-alkyl optionally substituted by phenyl which itself is optionally substituted by C1-4-alkyl, C1-4-alkoxy, halogen or phenyl have valuable pharmacological properties.

557191

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