11.beta.-halogen-7.alpha.-substituted estratrienes, process...

C - Chemistry – Metallurgy – 07 – J

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C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61K 31/58 (2006.01) C07J 31/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2316444

This invention describes the new 11.beta.-halogen-7.alpha.-substituted estratrienes of general formula I (see formula I) in which R11 is a fluorine or chlorine atom, and the other substituents have the meanings that are explained in more detail in the description. The compounds have antiestrogenic properties or tissue--selective estrogenic properties and are suitable for the production of pharmaceutical agents.

L'invention concerne de nouveaux estratriènes 11 beta -halogène-7 alpha -substitués de la formule générale (I) dans laquelle R<11> désigne un atome de fluor ou de chlore et les autres substituants ont les significations mentionnées dans la description. Ces composés présentent des propriétés à action anti-oestrogène ou oestrogène à sélectivité tissulaire et s'utilisent pour préparer des médicaments.

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