C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/08 (2006.01) A61K 31/4196 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2488592
Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11.beta.-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.
La présente invention concerne des composés représentés par la formule (I), y-compris des sels, des hydrates et des solvates pharmaceutiquement admis de ces composés. Ces produits constituent des inhibiteurs sélectifs de l'enzyme 11?-HSD1. Les composés de l'invention conviennent ainsi au traitement du diabète, et notamment du diabète non insulino-dépendant, de l'hyperglycémie, de l'obésité, de la résistance à l'insuline, de la dyslipidémie, de l'hyperlipémie, de l'hypertension, du syndrome X, et d'autres symptômes associés au diabète non insulino-dépendant.
Balkovec James M.
Olson Steven H.
Zhu Yuping
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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