11 .beta.-phenyl-4,9,15-estratrienes their manufacture and...

Details 11 .beta.-phenyl-4,9,15-estratrienes their manufacture and... 11 .beta.-phenyl-4,9,15-estratrienes their manufacture and...

C - Chemistry, Metallurgy

07

J

167/191, 260/38,

C07J 1/00 (2006.01) A61K 31/565 (2006.01) C07J 21/00 (2006.01) C07J 41/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 1320946

ABSTRACT New 11.beta. phenyl-4,9,15-estratrienes of formula I Image ( I ) are described, where X implies an oxygen atom or a hydroxyimino grouping N~OH, R1 stands for a hydrogen atom or a methyl group, R2 implies a hydrogen atom, an alkyl radical or an acyl radical with in each case 1 to 10 carbon atoms, R3 stands for a hydrogen atom, a cyanomethyl group, -(CH2)nCH2Z where n implies the numbers 0, 1, 2, 3, 4 or 5, Z = -H or -OR5 with R5 having the significance of a hydrogen atom or an alkyl or acyl group with in each case 1 to 10 carbon atoms, or for -(CH2)m-C=C-Y where m = 0 - 2 and Y implies a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxy- alkyl or acyloxyalkyl group with in each case 1 to 10 carbon atoms, R4 represents a straight-chain or branched-chain, saturated or unsaturated hydrocarbon radical with up to 8 carbon atoms which contains the grouping Image with X having the above significance. The compounds have antigestagenic and antiglucocorticoid activity.

572238

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