11 beta-substituted progesterone analogs

Details 11 beta-substituted progesterone analogs 11 beta-substituted progesterone analogs

C - Chemistry, Metallurgy

07

J

260/11, 167/191,

C07J 7/00 (2006.01) A61K 31/56 (2006.01) C07J 13/00 (2006.01) C07J 41/00 (2006.01) C07J 53/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1338906

A 11.beta.-aryl-19-norprogesterone steroid of the formula: Image wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5, wherein R5 is C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl or aryl, R2 is H, R3 is H, C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl, R4 is H, CH3, F or Cl, R6 is H, (CH3)2N, CH3O, CH3CO, CH3S, CH3SO, CH3SO2, and X is O or NOCH3; or (ii) R1 and R2 taken together are a carbon-carbon bond and R3, R4, R6 and X are as defined above; or (iii) R1 and R3 taken together are -CH2- or -N=N-CH2-, R2 is H and R4, R6 and X are as defined above; or (iv) R2 and R3 taken together are =CH2 and R1, R4, R6 and X are as defined above.

603686

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