11-phenyl-dibenzodiazepine derivatives as rxr-antagonists

Details 11-phenyl-dibenzodiazepine derivatives as rxr-antagonists 11-phenyl-dibenzodiazepine derivatives as rxr-antagonists

C - Chemistry, Metallurgy

07

D

C07D 243/38 (2006.01) A61K 31/551 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2521337

The present invention relates to novel benzodiazepine compounds exhibiting RXR- antagonist efficacy, for delaying progression of, preventing or treating a condition or disease being associated with RXR-antagonism, in particular selected from diabetes, complication of diabetes such as retinopathy, nephropathy, neuropathy, and hyperlipidemia, obesity, dyslipidemia, and osteoporosis.

L'invention concerne de nouveaux composés de benzodiazépine efficaces en tant qu'antagonistes du RXR. Ces composés servent à ralentir la progression d'un trouble ou d'une maladie, à prévenir ou à traiter un trouble ou une maladie associés à l'antagonisme du RXR, notamment un maladie comme le diabète, le diabète de type 2, les complications dues au diabète telles que la rétinopathie, la néphropathie, la neuropathie et l'hyperlipidémie, l'obésité, la dyslipidémie et l'ostéoporose.

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