11beta-hydroxysteroid dehydrogenase type 1 active compounds

Details 11beta-hydroxysteroid dehydrogenase type 1 active compounds 11beta-hydroxysteroid dehydrogenase type 1 active compounds

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/4025 (2006.01) A61P 3/04 (2006.01) A61P 9/12 (2006.01) C07D 207/10 (2006.01) C07D 207/12 (2006.01) C07D 207/14 (2006.01) C07D 207/16 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 471/08 (2006.01) C07D 491/08 (2006.01)

Patent

CA 2657078

The use of substituted amides for modulating the activity of 11.beta.-hydroxysteroid dehydrogenase type 1 (11.beta.HSD1 ) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, of the general formula I. Their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11.beta.HSDI and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

L'invention concerne l'utilisation d'amides substitués pour moduler l'activité de la 11.beta.-hydroxystéroïde déshydrogénase de type 1 (11.beta.HSD1 ) et l'utilisation de ces composés comme compositions pharmaceutiques. L'invention concerne également une nouvelle classe d'amides substitués représentés par la formule générale I, leur utilisation thérapeutique, des compositions pharmaceutiques contenant lesdits composés, ainsi que leur utilisation dans la fabrication de médicaments. Lesdits composés sont des modulateurs et, plus spécifiquement, des inhibiteurs de l'activité de 11.beta.HSDI et peuvent être utilisés dans le traitement de divers troubles médicaux dans lesquels est souhaitable une concentration intracellulaire réduite d'un glucocorticoïde actif.

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