12- and 13-bromoergoline derivatives

Details 12- and 13-bromoergoline derivatives 12- and 13-bromoergoline derivatives

C - Chemistry, Metallurgy

07

D

260/206, 167/227

C07D 457/12 (2006.01) A61K 31/48 (2006.01)

Patent

CA 1291121

ABSTRACT OF THE DISCLOSURE Novel 12- and 13-bromoergoline derivatives of the for- mula Image (I) wherein R is hydrogen or C1-2-alkanoyl, R1 is hydrogen, bromine, or C1-2-alkylthio, wherein at least one of R and R1 is H, and when Br is in the 12-position, R1 is H, and when R1 is bromine C2 Image C3 is a double bond, R2 is lower alkyl, R3 is NH-CO-NEt2 or NH-CS-NEt2, C9 Image C10 and C2 Image C3 each independently is a CC- single or a C=C-double bond, and the hydrogen atom in the 10- position is in the .alpha.-configuration if C9 Image C10 is a CC-single bond, and the hydrogen atom in the 3-position is in the .alpha.- configuration or .beta.-configuration if C2 Image C3 is a CC-single bond, or a pharmaceutically acceptable acid addition salt thereof are suitable as medicines for treating psychic disorders of the depressive array of symptoms and also as intermediates.

518528

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