12-aryl prostaglandin analogs

Details 12-aryl prostaglandin analogs 12-aryl prostaglandin analogs

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/5575 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2589864

Compounds comprising the formula (I) are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the .omega.-chain comprises a substituted phenyl, wherein at least one substituent consists of hydrocarbyl or non-linear hydroxyhydrocarbyl is also disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed.

Cette invention concerne des composés de formule (I) dans laquelle Y, A, X, R, D, et n sont décrits. L'invention concerne également un composé renfermant un agoniste sélectif EP2 de prostaglandine, la chaîne ? comprenant un phényle substitué, un substituant au moins étant constitué d'hydrocarbyle ou d'hydroxyhydrocarbyle non linéaire. L'invention concerne également des procédés, des compositions et des médicaments associés à ces composés.

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