12(s)-hete receptor blockers

Details 12(s)-hete receptor blockers 12(s)-hete receptor blockers

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/00 (2006.01) A61K 31/045 (2006.01) A61K 31/05 (2006.01) A61K 31/20 (2006.01) A61K 31/4178 (2006.01) A61K 31/5377 (2006.01) A61K 38/16 (2006.01) A61K 39/05 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2303935

The 12-lipoxygenase product, 12(S)-HETE, mediates hyperproliferative and hyperplastic responses seen in atherosclerosis, diabetes, Parkinson's disease, Alzheimer's, stroke-induced nerve damage and cancer. 12-HETE also mediates inflammation and cell death in some cell systems, particularly B-islet cells of the pancreas. The present invention involves amelioration of disease states mediated by 12(S)-HETE by blocking specific 12(S)-HETE receptors.

Le produit de la 12-lipoxygénase, 12(S)-HETE, induit des réponses hyperprolifératives et hyperplasiques, telles qu'on peut les constater dans l'athérosclérose, le diabète, la maladie de Parkinson, la maladie d'Alzheimer, les lésions nerveuses induites par un ictus et le cancer. 12-HETE induit également l'inflammation et la mort cellulaire dans certains systèmes cellulaires, notamment les îlots pancréatiques B. La présente invention vise à améliorer des états maladifs induits par 12(S)-HETE, par blocage des récepteurs spécifiques de 12(S)-HETE.

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