12b-substituted 1-hydroxymethyl-octahydroindolo¬2,3-a|-...

C - Chemistry – Metallurgy – 07 – D

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C07D 455/00 (2006.01) A61K 31/44 (2006.01) C07D 471/14 (2006.01)

Patent

CA 1300146

12b-Substituted 1-hydroxymethyl-octahydroindolo[2,3-a]- quinolizine derivatives, process for the preparation and pharmaceutical compositions containing them A b s t r a c t The invention relates to new racemic and optically active 12b-substituted 1-hydroxymethyl-octahydroindolo- [2,3-a]quinolizine derivatives of the formula (I) Image (I) wherein R1 and R2 are the same or different and represent hydrogen, halogen, nitro, amino, hydroxyl, alkyl having from 1 to 6 carbon atoms or alkoxy having from 1 to 6 carbon atoms; R3 and R5 are the same or different and represent hydrogen, alkyl having from 1 to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety; R4 is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety; - 2 - R6 is hydrogen or alkyl having from 1 to 6 carbon atomo, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, and isomere and acid additions salts thereof. The compounds of the invention are partly valuable intermediates, partly are pharmaceutically active themselves.

507054

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