13-alkyl-11beta-phenylgonanes

Details 13-alkyl-11beta-phenylgonanes 13-alkyl-11beta-phenylgonanes

C - Chemistry, Metallurgy

07

J

167/191, 260/7

C07J 33/00 (2006.01) C07J 1/00 (2006.01) C07J 15/00 (2006.01) C07J 17/00 (2006.01) C07J 41/00 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1334668

This invention relates to 13-alkyl-11beta-phenyl-gonanes of the following general Formula I Image (I). in which Z is =O or =N-OH, R1 is a cyclic or heterocyclic radical, or C2-10-alkenyl, R2 is .alpha. or .beta. -CH3 or -C2H5 and R3/R4 are various organic groups. The compounds of general Formula I have a strong affinity for the gestagen receptor, without themselves developing gestagen activity. They are competitive antagonists of the progesterone (anti-gestagens); since they displace from the receptor the progesterone necessary for maintaining pregnancy, they are suitable for triggering abortions and for inducing birth.

604596

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