13 human colon and colon cancer associated proteins

Details 13 human colon and colon cancer associated proteins 13 human colon and colon cancer associated proteins

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385487

This invention relates to newly identified colon or colon cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "colon cancer antigens", and the use of such colon antigens for detecting disorders of the gastrointestinal system, particularly the presence of colon cancer and colon cancer metastases. This invention relates to colon cancer antigens as well as vectors, host cells, antibodies directed to colon cancer antigens and the recombinant methods and synthetic methods for producing the same. Also provided are diagnostic methods for detecting, treating, preventing and/or prognosing disorders related to the colon, including colon cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of colon cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polypeptides of the present invention.

La présente invention concerne l'identification de polynucléotides liés au colon ou au cancer du colon et les polypeptides codés par ces polynucléotides appelés ici de façon collective <=antigènes du cancer du colon>=, et l'utilisation de ces antigènes du colondans la détection des troubles du tube digestif, et plus particulièrement de la présence du cancer du colon et de métastases du cancer du colon. Cette invention concerne des antigènes du cancer du colon, de même que des vecteurs, des cellules hôtes, des anticorps dirigés contre ces antigènes du cancer du colon et des technique de recombinaison et de synthèse permettant la production de ceux-ci. Cette invention concerne aussi des techniques diagnostiques permettant de détecter, traiter, prévenir et/ou de pronostiquer des pathologies liées au colon, notamment le cancer du colon, et des techniques thérapeutiques permettant de traiter ces pathologies. Cette invention concerne encore des méthodes de recherche permettant d'identifier des agonistes et des antagonistes des antigènes du cancer du colon de l'invention. Enfin cette invention traite de la façon d'inhiber la production et la fonction des polypeptides de l'invention.

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