13-membered azalides and their use as antibiotic agents

Details 13-membered azalides and their use as antibiotic agents 13-membered azalides and their use as antibiotic agents

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01) A61K 31/7052 (2006.01)

Patent

CA 2351429

The invention relates to a method of preparing compounds of formula (1) and to pharmaceutically acceptable salts thereof. The compounds of formula (1) are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing the compounds of formula ( 1 ) and to methods of treating bacterial protozoa infections by administering the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1) and to intermediates useful in such preparation.

L'invention concerne un procédé de préparation des composés correspondant à la formule (1) et de leurs sels pharmaceutiquement acceptables. Les composés correspondant à la formule (1) sont des agents antibactériens qui peuvent être utilisés pour traiter diverses infections par bactéries protozoaires. L'invention concerne aussi des compositions pharmaceutiques contenant des composés correspondant à la formule (1) et des procédés pour traiter les infections par bactéries protozoaires en administrant les composés correspondant à la formule (1). L'invention concerne enfin des procédés de préparation des composés correspondant à la formule (1) et des intermédiaires utiles dans ce processus.

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