13-thiaprostaglandin derivatives

Details 13-thiaprostaglandin derivatives 13-thiaprostaglandin derivatives

C - Chemistry, Metallurgy

07

F

260/235.01

C07F 9/54 (2006.01) C07C 405/00 (2006.01) C07D 303/04 (2006.01) C07D 303/40 (2006.01)

Patent

CA 1120927

ABSTRACT OF THE DISCLOSURE 13-Thiaprostanoic acid derivatives of the general Formula I Image (I) wherein A is -CO- or -CHOH-; B is -CH2CH2- or -CH=CH-; Q is 1,4-phenylene or 1,4-naphthylene; R1 is H or OH; R2 is H or CH3; R3 is alkyl with 1 - 8 carbon atoms or alkyl with 1 - 8 carbon atoms substituted by (a) phenyl, (b) phenyl. substituted by at least one of CH3, F, Cl, Br, OH, OCH3 or CF3; (c) phenoxy or (d) phenoxy substituted by at least one of CH3, F, Cl, Br, OH, OCH3 or CF3; and R4 is NH2, CH3, phenyl, p-acetylaminophenyl, p-benzoylaminophenyl or phenylamino. These compounds are useful for lowering blood pressure as well as for other pharmaceutical purposes. They also are useful inter- mediates for the preparation of other known pharmaceuticals such as the 13-thiaprostaglandins. MERCK 418

288185

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