13c, 15n, 2h labeled proteins for nmr structure...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/00 (2006.01) C07B 59/00 (2006.01) C07K 14/59 (2006.01) C12N 1/00 (2006.01) C12N 5/00 (2006.01) C12P 21/00 (2006.01) G01N 24/08 (2006.01) G01N 33/68 (2006.01) G01R 33/465 (2006.01) C07K 1/13 (2006.01)

Patent

CA 2301046

This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

L'invention concerne un processus de détermination de la structure tridimensionnelle de macromolécules biologiques telles que des protéines. Elle concerne notamment des procédés servant à déterminer rapidement la structure d'une protéine par RMN, au moyen de processus destinés à simplifier les spectres RMN à l'aide de protéines marquées et préparées à partir d'acides aminés marqués de manière spécifique et isotope et possédant dans leur squelette au moins deux isotopes de 13C, 15N et 2H. L'invention concerne également des processus de préparation de ces protéines marquées, par exemple par utilisation d'une culture microbienne contenant ces acides aminés marqués.

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