14,15-substituted lanosterols and their use as...

Details 14,15-substituted lanosterols and their use as... 14,15-substituted lanosterols and their use as...

C - Chemistry, Metallurgy

07

J

167/195, 260/60,

C07J 9/00 (2006.01) A61K 31/575 (2006.01) C07J 41/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1328449

TITLE 14,15-SUBSTITUTED LANOSTEROLS AND THEIR USE AS HYPOCHOLESTEROLEMIC AGENTS ABSTRACT OF THE DISCLOSURE Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-1,24-dien-3.beta.-ol 14.alpha.-methyl-demethylase activity, supressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol synthesis and reducing serum cholesterol levels are disclosed.

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