14(15)-unsaturated 15- and/or 16- substituted androgens with...

Details 14(15)-unsaturated 15- and/or 16- substituted androgens with... 14(15)-unsaturated 15- and/or 16- substituted androgens with...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61P 5/26 (2006.01) A61P 5/34 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2431328

Disclosed are androgen-related steroids having a .DELTA.14 double bond and carrying a substituent at either or both of the carbon atoms nos. 15 and 16. The present steroids are characterized by possessing a mixed profile of androgenic and progestagenic activities. This makes these compounds suitable for male or female hormone replacement therapy, as well as male contraception.

L'invention concerne des stéroïdes associés aux androgènes ayant une double liaison .DELTA.?14¿ et portant un substituant à l'un ou l'autre ou aux deux atomes de carbone numéros 15 et 16. Les stéroïdes de la présente invention sont caractérisés en ce qu'ils possèdent un profil mixte d'activités androgènes et progestatives. Ceci rend ces composés appropriés à une hormonothérapie substitutive chez l'homme ou la femme, de même que pour la contraception chez l'homme.

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