A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/08 (2006.01) A61K 45/00 (2006.01) A61P 19/02 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01)
Patent
CA 2706479
Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14- 3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical composition and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3.
L'invention propose des compositions et des procédés pour le traitement de l'arthrite.
Ghahary Aziz
Kilani Ruhangiz
Maksymowych Walter Wolodymyr Peter
Marotta Anthony
Smart & Biggar
The University Of British Columbia
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