14-alpha, 17-alpha-bridged 16-hydroxyestratrienes

Details 14-alpha, 17-alpha-bridged 16-hydroxyestratrienes 14-alpha, 17-alpha-bridged 16-hydroxyestratrienes

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/565 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2069880

ABSTRACT The new 14.alpha.,17.alpha.-bridged estratrienes of general formula I Image (I), are described in which if OR3 is in .alpha.-position R1, R2 and R3, independent of one another, stand for a hydrogen atom, an acyl group -?-R4, in which R4 is an organic radical with up to 11 carhon atoms or radical -(CH2)nCOOH with n = 1-4 is a carboxylic acid, and, further, R1 stands for a benzyl radical, C1-C8 alkyl radical or C3-C5 cycloalkyl radical and if OR3 is in .beta.-position R1, R2 and R3, independent of one another, stand for a hydrogen atom, an acyl group with 1 to 12 carbon atoms and R1 in addition stands for a C1-C8 alkyl radical and in both cases, A-B means an etheno- or ethano-bridge, and a process for their production. The new compounds are very strong estrogens and are suitable for the production of pharmaceutical agents.

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