14.alpha., 17.alpha.-ethanoestratrienes

C - Chemistry – Metallurgy – 07 – J

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167/193, 260/46

C07J 53/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2002692

Abstract There are described new 14a1pha,17alpha-ethanoestratrienes general formula I Image (I), in which R1 means a hydrogen atom, an alkyl or acyl group with 1 to 12 carbon atoms, R2 means a hydrogen atom or a methyl group, R3 a hydrogen atom or an acyl group with 1 to 12 carbon atoms and either Image or Image in which R4 is an alpha-position or beta-position alkyl radical with 1 to 8 carbon atoms or an alpha,beta-alkenyl radical optionally exhibiting several double bonds or an alpha,beta alkinyl radical, both with 2 to 8 carbon atoms, as well as a process for their production. The new compounds have strong estrogenic effectiveness.

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