14-beta-gal mammalian lectins

Details 14-beta-gal mammalian lectins 14-beta-gal mammalian lectins

C - Chemistry, Metallurgy

12

N

530/15.14, 195/1

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338878

Human HL-60 lectin having an amino acid sequence different from other known animal lectins is disclosed. This is one member of a class of mammalian lectins extractable in lactose or detergent and specific for beta- D-galactosides (14-beta-gal lectin which contains at least one glycosylation site). Recombinant methods and materi- als for production of the mammalian 14-beta-gal lectins, especially HL-60 lectin, in a variety of hosts, and methods to utilize the resulting lectins are also described. Human HL-60 lectin is found in HL-60 cells and in placental tissue.

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