14.beta.-h-, 14- and 15-en-11.beta.-aryl-4-estrenes

Details 14.beta.-h-, 14- and 15-en-11.beta.-aryl-4-estrenes 14.beta.-h-, 14- and 15-en-11.beta.-aryl-4-estrenes

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 1/00 (2006.01) C07J 3/00 (2006.01) C07J 7/00 (2006.01) C07J 9/00 (2006.01) C07J 17/00 (2006.01) C07J 21/00 (2006.01) C07J 33/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2099016

ABSTRACT OF THE DISCLOSURE New compounds having the general formula (I), as well as their pharmacologically acceptable addition salts with acids, are disclosed. In the formula (I), either (Ia) R11 stands for a hydrogen atom in the .beta. position, whereas R12 and R13- each represent a hydrogen atom, or (Ib) R11 stands for a hydrogen atom in the .beta. position, whereas R12 and R13 together represent a second bond, or (Ic) R11 and R12 together represent a second bond, whereas R13 stands for a hydrogen atom, or (Id) R11 stands for a hydrogen atom in the .alpha. position, whereas R12 and R13 together represent a second bond. In all cases (Ia, Ib, Ic, or Id), X stands for an oxygen atom, the hydroxymino grouping > N ? OH or two hydrogen atoms, R1 stands for a hydrogen atom or a methyl group; R2 stands for a hydroxy group, a C1-C10 alkoxy or C1- C10 acyloxy group, whereas R3 and R4 have the usual meanings for competitive pregesterone antagonists, given in the description. Also disclosed are processes for producing these new compounds, pharmaceutical compositions containing these compounds, their use to produce medicaments and new intermediate products required for the process. These new compounds have a strong affinity for the gestagen receptor, as well as strong antigestagenous, antiglucorticoidal, antimineralcorticoidal and antiandrogenous properties.

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