14-methoxymorphinan-6-one compounds

Details 14-methoxymorphinan-6-one compounds 14-methoxymorphinan-6-one compounds

C - Chemistry, Metallurgy

07

D

260/237.69

C07D 405/06 (2006.01) C07D 221/28 (2006.01)

Patent

CA 1136130

Docket No. 11861 14- METHOXYMOXYMORPHINAN-6-ONE COMPOUNDS ABSTRACT OF THE DISCLOSURE Disclosed are 14-methoxy substituted 3-hydroxy or 3-methoxy -6-one morphinans characterized by the structural formula: Image wherein R is H or methyl; R1 is H, .alpha. methyl or .beta. methyl; and R2 is cyclobutylmethyl, cyclopropylmethyl, tetrahydrofurfuryl or dimethylallyl. The compounds of the present invention are variously useful as analgesics, narcotic antagonists and mixed analgesics /narcotic antagonists.

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