14273 receptor, a g-protein coupled receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2331886

The present invention relates to a receptor belonging to the superfamily of G- protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.

L'invention concerne un récepteur, appartenant à la superfamille des récepteurs couplés à une protéine G. L'invention concerne également des polynucléotides codant pour le récepteur. L'invention concerne en outre des procédés utilisant des polypeptides et polynucléotides récepteurs comme cibles pour le diagnostic et le traitement d'affections à médiation par récepteur. L'invention concerne également des procédés de sélection de médicaments au moyen de polypeptides et polynucléotides récepteurs pour identifier des agonistes et des antagonistes pour diagnostic et traitement. L'invention a également trait aux agonistes et antagonistes à base de polypeptides et polynucléotides récepteurs, ainsi qu'à des procédés d'obtention desdits polypeptides et polynucléotides récepteurs.

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