14274 receptor, a g-protein coupled receptor related to the...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2340334

The present invention relates to a newly identified member of the superfamily of G-protein-coupled receptors, and a new member of the EDG receptor family. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.

L'invention concerne un élément nouvellement identifié de la superfamille des récepteurs couplés à la protéine G, et représentant un nouveau membre de la famille des récepteurs EDG. L'invention concerne en outre des polynucléotides codant le récepteur, ainsi que des procédés relatifs à l'utilisation de polypeptides et de polynucléotides récepteurs comme cible pour le diagnostic et le traitement liés aux troubles dont la médiation est assurée par des récepteurs. L'invention concerne également des procédés de criblage des médicaments, faisant appel auxdits polypeptides et polynucléotides récepteurs, de manière à identifier des agonistes et des antagonistes aux fins de diagnostic et de traitement. L'invention concerne par ailleurs des agonistes et des antagonistes reposant sur les polypeptides et les polynucléotides récepteurs considérés. L'invention concerne enfin des procédures relatives à l'élaboration desdits polypeptides et polynucléotides récepteurs.

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