C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 53/00 (2006.01) A61K 31/58 (2006.01) A61P 5/28 (2006.01) A61P 5/34 (2006.01) A61P 5/42 (2006.01)
Patent
CA 2708394
The invention relates to 15,16-methylene-17-hydroxy-19- nor-2l-carboxylic acid-steroid y-lactone derivatives with the general chemical formula I, and R4, R6a, R6b, R7 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action. See Formula 1 I
L'invention concerne un dérivé de stéroïde ?-lactone de l'acide 15,16-méthylène-17-hydroxy-19-nor-21-carboxylique de formule chimique générale (I), dans laquelle R4, R6a, R6b, R7 et Z ont les significations indiquées dans la revendication 1, ainsi que leurs solvates, leurs hydrates, leurs stéréoisomères et leurs sels. L'invention concerne également l'utilisation de ces dérivés dans la fabrication d'un médicament destiné à la contraception orale et au traitement de troubles pré-, péri- et post-ménopausiques ainsi que des médicaments contenant des dérivés de ce type. Les dérivés selon l'invention possèdent un effet gestagène et, dans des cas préférés, un effet antiminéralocorticoïde et neutre jusqu'à légèrement androgène.
Bohlmann Rolf
Borden Steffen
Frenzel Thomas
Huebner Jan
Klar Ulrich
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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