15-deoxyprostaglandin derivatives

Details 15-deoxyprostaglandin derivatives 15-deoxyprostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2054738

The present invention relates to a 15- deoxyprostaglandin derivative of the formula (V): Image Image in which is a 5-membered ring which is selected from the group consisting of Image and Image R1 is hydrogen or C1-C5 alkyl; R4 is C5-C11 alkyl, C5-C11 alkenyl or C5-C11 alkadienyl; or pharmaceutically acceptable salts thereof, with the proviso that compounds of the following formulae are excluded: Image wherein Image is Image or Image or Image and wherein R4 is C5-C11 alkyl or pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical formulation comprising a 15- deoxyprostaglandin derivative as an active ingredient. The derivatives and formulations of the present invention are useful as intraocular pressure reducing agents.

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